Mn2+ prevents the Ca2+ -induced inhibition of ATP synthesis in brain mitochondria

Hillered, Lars; Muchiri, Peter M.; Nordenbrand, Kerstin; Ernster, Lars

dc.contributor.author	Hillered, Lars
dc.contributor.author	Muchiri, Peter M.
dc.contributor.author	Nordenbrand, Kerstin
dc.contributor.author	Ernster, Lars
dc.date.accessioned	2024-11-11T08:47:00Z
dc.date.available	2024-11-11T08:47:00Z
dc.date.issued	1983-02-26
dc.identifier.uri	https://doi.org/10.1016/0014-5793(83)80158-6
dc.identifier.uri	https://repository.dkut.ac.ke:8080/xmlui/handle/123456789/8753
dc.description.abstract	Uptake of Ca2+ by rat brain mitochondria causes an inhibition of respiratory stimulation by ADP, and the inhibition is relieved upon Na+-induced release of Ca2+ from the mitochondria, in accordance with earlier reports. We show that simultaneous uptake of Ca2+ and Mn2+ results in no inhibition of ADP-stimulated respiration, indicating that Mn2+ prevents the Ca2+-induced inhibition of ATP synthesis, without preventing Ca2+ accumulation in the mitochondria. The results are discussed in relation to a possible involvement of the mitochondrial ATPase-inhibitor protein in the observed effects of Ca2+ and Mn2+.	en_US
dc.language.iso	en	en_US
dc.subject	ATP synthesisADP	en_US
dc.subject	stimulated respirationCa2	en_US
dc.subject	induced inhibitionMn2+	en_US
dc.subject	antagonismBrain mitochondriaATPase-inhibitor protein	en_US
dc.title	Mn2+ prevents the Ca2+ -induced inhibition of ATP synthesis in brain mitochondria	en_US
dc.type	Article	en_US