Abstract:
The increased prevalence of mental disorders is a major public health concern in both the developing and
developed world. The pathogenesis of cognitive impairment and mental disorders are largely attributed to the oxidative
damage and neuroinflammation in memory-related brain cells and tissues resulting in reduced efficiency in brain functions.
Several epidemiological studies show flavonoids and vitamin E may reduce the neuronal damage leading to improved mental
health, and the underlying mechanisms for these effect include their antioxidant properties, neuroprotective action in the
brain tissues by protecting the neurons against injury, activation of synaptic signalling by enhancing neuronal regeneration
and stimulation of the synaptic plasticity; and improvement of the cerebrovascular peripheral blood flow. Thus, this paper
emphasizes the potential role of nutritional interventions as a promising strategy towards improving cognitive function and
mental health. In particular, we broadly review the evidence for the potential role of flavonoids and vitamin E in modulating
cognitive function and psychiatric health. We further examine the potential underlying cellular and molecular mechanisms
for their effects in brain function and improved mental health.
