Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase

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dc.contributor.author Oluoch Linus Lincone
dc.contributor.author Mbugua Paul Mungai
dc.contributor.author Boniface Mwangi Chege
dc.contributor.author Muriithi Anne Wangechi
dc.contributor.author Siringo Cyril George
dc.contributor.author Wafula David Kayaja
dc.date.accessioned 2020-05-15T12:06:12Z
dc.date.available 2020-05-15T12:06:12Z
dc.date.issued 2019-06
dc.identifier.uri http://repository.dkut.ac.ke:8080/xmlui/handle/123456789/1135
dc.description.abstract Many patients in Africa often utilize herbal medicine for the management of hyperactive gut disorders such as diarrhea and abdominal colic. There is therefore a need to scientifically evaluate efficacy of this herbal remedies. This study investigated the myorelaxant effect of Carissa edulis (Forssk.) Vahl and its possible mechanism of action using isolated rabbit jejunum preparations. Pieces of jejunum were isolated from adult New Zealand white rabbits. They were then mounted in an organ bath containing Tyrode’s solution. The rate and force of jejunal contraction were recorded and analyzed using a Powerlab that was coupled to Chart5 software for windows. The effects of the extract (0.1-10.0 mg/ml) on spontaneous contraction were investigated. Its effect (3.0 mg/ml) was also studied in the presence of L G -NAME (nitric oxide synthase inhibitor), methylene blue (soluble guanylyl cyclase inhibitor) and propranolol (non-selective β adrenergic receptors antagonist). The extract dose-dependent significantly decreased the force but not the rate of spontaneous rabbit jejunal contraction. Among the blockers used, only LG -NAME significantly blocked the effect of the extract. Aqueous root bark extracts of C. edulis possess significant myorelaxant effect on isolated rabbit jejunum. This appears to be mediated through stimulation of nitric oxide release by nitric oxide synthase. en_US
dc.language.iso en en_US
dc.publisher African Journal of Pharmacy and Pharmacology en_US
dc.title Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase en_US
dc.type Article en_US


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